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Article

Antigen binding of human IgG Fabs mediate ERK-associated proliferation of human breast cancer cells.

DNA and cell biology - 1 Feb 2005

Wen Yue-Jin, Mancino Anne, Pashov Anastas, Whitehead Tracy, Stanley Joseph, Kieber-Emmons Thomas

Abstract excerpt

Serum-circulating antibody can be linked to poor outcomes in some cancer patients. To investigate the role of human antibodies in regulating tumor cell growth, we constructed a recombinant cDNA expression library of human IgG Fab from a patient with breast cancer. Clones were screened from the library with breast tumor cell lysate. Sequence analysis of the clones showed somatic hypermutations when compared to...

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Identifiers

PMID: 15699628
DOI: 10.1089/dna.2005.24.73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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