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Article

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.

Neuromuscular disorders : NMD - 1 Jan 2000

Yamaoka L H, Westbrook C A, Speer M C, Gilchrist J M, Jabs E W, Schweins E G, Stajich J M, Gaskell P C, Roses A D, Pericak-Vance M A

Abstract excerpt

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using...

Topics

Chromosome Mapping
DNA, Satellite
Genetic Linkage
Genotype
Haplotypes
Humans
Lod Score
Muscular Dystrophies
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7881291
DOI: 10.1016/0960-8966(94)90086-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7881291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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