Article
Linkage analyses between dominant X-linked Charcot-Marie-Tooth disease, and 15 Xq11-Xq21 microsatellites in a new large family: three new markers are closely linked to the gene.
Neuromuscular disorders : NMD - 1 Jan 2000
Le Guern E, Ravise N, Gugenheim M, Vignal A, Penet C, Bouche P, Weissenbach J, Agid Y, Brice A
Abstract excerpt
X-linked dominant inheritance was suspected in a large family with Charcot-Marie-Tooth disease since no male to male transmission was observed, and since the sensory and motor neuropathy was more severe in males than in females. To test linkage to the dominant X-linked Charcot-Marie-Tooth disease...
Topics
- Blotting, Western
- Charcot-Marie-Tooth Disease
- Chromosome Mapping
- DNA, Satellite
- Female
- Genes, Dominant
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Male
- Pedigree
- Polymerase Chain Reaction
- Receptors, Androgen
- X Chromosome