Localization of a locus for Charcot-Marie-Tooth neuropathy type Ia (CMT1A) to chromosome 17.

doi:10.1016/0888-7543(90)90175-t

Back to search

Article

Localization of a locus for Charcot-Marie-Tooth neuropathy type Ia (CMT1A) to chromosome 17.

Genomics - 1 Jul 1990

McAlpine P J, Feasby T E, Hahn A F, Komarnicki L, James S, Guy C, Dixon M, Qayyum S, Wright J, Coopland G

Abstract excerpt

Phenotypic data for 71 genetic markers for members of five Caucasian kindreds were tested for linkage with the autosomal dominant mutations causing Charcot-Marie-Tooth (hereditary motor sensory) neuropathy type I, characterized by markedly reduced nerve conduction velocities. Lod score analysis g...

Topics

Charcot-Marie-Tooth Disease
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genes, Dominant
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Muscular Atrophy, Spinal
Mutation
Pedigree
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.