Article
Obese Zucker (fa/fa) rats exhibit normal target sensitivity to corticosterone and increased drive to adrenocorticotropin during the diurnal trough.
Endocrinology - 1 Dec 1992
Walker C D, Scribner K A, Stern J S, Dallman M F
Abstract excerpt
Genetically obese Zucker (fa/fa) rats exhibit numerous metabolic and endocrine disorders associated with modest hypercorticosteronemia and reported changes in peripheral target tissue sensitivity to glucocorticoids. In this study we investigated phenotypic differences in basal and stress-induced...
Topics
- Adipose Tissue
- Adrenal Cortex
- Adrenalectomy
- Adrenocorticotropic Hormone
- Animals
- Circadian Rhythm
- Corticosterone
- Feedback
- Insulin
- Insulin Secretion
- Male
- Obesity
- Organ Size
- Phenotype
- Rats
- Rats, Zucker
- Stress, Physiological
- Thymus Gland