Article
Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study.
The Journal of clinical endocrinology and metabolism - 1 Jan 2002
Pasquali Renato, Ambrosi Bruno, Armanini Decio, Cavagnini Francesco, Uberti Ettore Degli, Del Rio Graziano, de Pergola Giovanni, Maccario Mauro, Mantero Franco, Marugo Mario, Rotella Carlo Maria, Vettor Roberto
Abstract excerpt
There is increasing evidence that the abdominal obesity phenotype may be associated with multiple alterations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in both sexes. Our hypothesis is that the lack of adequate cortisol suppression after the dexamethasone test may constitute an indirect marker of HPA axis hyperactivity in the presence of the abdominal obesity phenotype. A total of 34...
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