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Article

PBP 2a mutations producing very-high-level resistance to beta-lactams.

Antimicrobial agents and chemotherapy - 1 Feb 2004

Katayama Yuki, Zhang Hong-Zhong, Chambers Henry F

Abstract excerpt

Resistance to the beta-lactam class of antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is mediated by PBP 2a, a synthetic bacterial cell wall penicillin-binding protein with a low affinity of binding to beta-lactams that is encoded by mecA. Beta-lactams that bind to PBP 2a with a high affinity and that are highly active against MRSA are under development. The potential for the emergence of...

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Source

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Identifiers

PMID: 14742194
DOI: 10.1128/AAC.48.2.453-459.2004
PMCID: PMC321522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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