All‑trans retinoic acid alters the expression of the�tight�junction proteins Claudin‑1 and ‑4 and epidermal barrier function‑associated genes in the epidermis

Abstract excerpt

All‑trans retinoic acid (ATRA) regulates skin cell proliferation and differentiation. ATRA is widely used in the treatment of skin diseases, but results in irritation, dryness and peeling, possibly due to an impaired skin barrier, although the exact mechanisms are unclear. The present study established an ATRA‑associated dermatitis mouse model (n=32) in order to examine the molecular mechanisms of skin barrier...

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