Article
Meiotic DNA breaks at the S. pombe recombination hot spot M26.
Molecular cell - 1 Apr 2002
Steiner Walter W, Schreckhise Randall W, Smith Gerald R
Abstract excerpt
The ade6-M26 allele of Schizosaccharomyces pombe creates a well-defined meiotic recombination hot spot that requires a specific sequence, 5'-ATGACGT-3', and the Atf1*Pcr1 transcription factor for activity. We find that M26 stimulates the formation of meiosis-specific double-strand DNA breaks at multiple sites surrounding M26. Like hot spot activity, breakage requires the M26 heptamer, Pcr1, and the general...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.