Article
In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.
The Journal of clinical investigation - 1 Feb 1995
Li J, Fang B, Eisensmith R C, Li X H, Nasonkin I, Lin-Lee Y C, Mims M P, Hughes A, Montgomery C D, Roberts J D
Abstract excerpt
Elevations of plasma total or LDL cholesterol are major risk factors for cardiovascular disease. Efforts directed at preventing and treating cardiovascular disease have often focused on reducing the levels of these substances in the blood. The Watanabe Heritable Hyperlipidemic Rabbit, which has e...
Topics
- Animals
- Apolipoprotein A-I
- Base Sequence
- Cholesterol, HDL
- Cholesterol, LDL
- DNA Primers
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Hyperlipidemias
- Liver
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction