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Article

In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.

The Journal of clinical investigation - 1 Feb 1995

Li J, Fang B, Eisensmith R C, Li X H, Nasonkin I, Lin-Lee Y C, Mims M P, Hughes A, Montgomery C D, Roberts J D

Abstract excerpt

Elevations of plasma total or LDL cholesterol are major risk factors for cardiovascular disease. Efforts directed at preventing and treating cardiovascular disease have often focused on reducing the levels of these substances in the blood. The Watanabe Heritable Hyperlipidemic Rabbit, which has exceedingly high plasma cholesterol levels resulting from an LDL receptor deficiency, provides an excellent animal model...

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PMID: 7860759
DOI: 10.1172/JCI117725
PMCID: PMC295550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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