Article
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.
Journal of lipid research - 1 Aug 1998
Brousseau M E, Wang J, Demosky S J, Vaisman B L, Talley G D, Santamarina-Fojo S, Brewer H B, Hoeg J M
Abstract excerpt
Familial hypercholesterolemia (FH), a disease caused by a variety of mutations in the low density lipoprotein receptor (LDLr) gene, leads not only to elevated LDL-cholesterol (C) concentrations but to reduced high density lipoprotein (HDL)-C and apolipoprotein (apo) A-I concentrations as well. Th...
Topics
- Animals
- Animals, Genetically Modified
- Apolipoprotein A-I
- Base Sequence
- DNA Primers
- Disease Models, Animal
- Gene Expression
- Genetic Therapy
- Heterozygote
- Homozygote
- Humans
- Hyperlipoproteinemia Type II
- Hypolipoproteinemias
- Kinetics
- Lipids
- Lipoproteins
- Lipoproteins, HDL
- Mutation