Article
Renal cancer in von Hippel-Lindau disease and related syndromes.
Nature reviews. Nephrology - 1 Sept 2013
Bausch Birke, Jilg Cordula, Gläsker Sven, Vortmeyer Alexander, Lützen Niklas, Anton Alexandra, Eng Charis, Neumann Hartmut P H
Abstract excerpt
Sporadic and hereditary forms of renal cell carcinoma (RCC), von Hippel-Lindau (VHL) disease and the familial paraganglioma syndromes are closely related in terms of their clinical, molecular, and genetic aspects. Most RCCs occur sporadically and the heritable fraction of RCC is estimated to be just 2-4%. An understanding of the molecular genetic basis, the disease-specific and gene-specific biology and the...
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