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Article

Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.

Biochemistry - 17 Apr 1990

Eisenstein E, Markby D W, Schachman H K

Abstract excerpt

The sigmoidal dependence of activity on substrate concentration exhibited by the regulatory enzyme aspartate transcarbamoylase (ATCase) of Escherichia coli is generally attributed to a ligand-promoted change in the quaternary structure of the enzyme. Although a global conformational change in ATCase upon the binding of ligands to some of the six active sites is well documented, a corresponding alteration in the...

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PMID: 2187530
DOI: 10.1021/bi00467a019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.PMID 2187530Read ↗

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