Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.

doi:10.1021/bi00467a019

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Article

Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.

Biochemistry - 17 Apr 1990

Eisenstein E, Markby D W, Schachman H K

Abstract excerpt

The sigmoidal dependence of activity on substrate concentration exhibited by the regulatory enzyme aspartate transcarbamoylase (ATCase) of Escherichia coli is generally attributed to a ligand-promoted change in the quaternary structure of the enzyme. Although a global conformational change in ATC...

Topics

Adenosine Triphosphate
Allosteric Regulation
Aspartate Carbamoyltransferase
Aspartic Acid
Binding Sites
Carbamyl Phosphate
Cytidine Triphosphate
Escherichia coli
Kinetics
Mutation
Phosphonoacetic Acid
Protein Conformation

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