Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).

doi:10.1210/jcem.80.2.7852512

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Article

Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).

The Journal of clinical endocrinology and metabolism - 1 Feb 1995

MacLean H E, Choi W T, Rekaris G, Warne G L, Zajac J D

Abstract excerpt

We have investigated androgen-binding properties of the androgen receptor (AR) in cultured suprapubic skin fibroblasts from six subjects with Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Binding of the synthetic androgen methyltrienolone (R1881) was measured in a monolayer assay, and Scatchard analysis was performed to determine the total number of binding sites and the apparent binding...

Topics

Aged
Atrophy
Base Sequence
Binding, Competitive
Fibroblasts
Humans
Male
Medulla Oblongata
Middle Aged
Molecular Probes
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscular Atrophy, Spinal

Phenotype

Point Mutation

Polymorphism, Genetic

Pubic Bone

Receptors, Androgen

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 7852512
DOI: 10.1210/jcem.80.2.7852512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7852512-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).PMID 7852512Read ↗

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