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Article

Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).

The Journal of clinical endocrinology and metabolism - 1 Feb 1995

MacLean H E, Choi W T, Rekaris G, Warne G L, Zajac J D

Abstract excerpt

We have investigated androgen-binding properties of the androgen receptor (AR) in cultured suprapubic skin fibroblasts from six subjects with Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Binding of the synthetic androgen methyltrienolone (R1881) was measured in a monolayer assay, and Scatchard analysis was performed to determine the total number of binding sites and the apparent binding...

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Source

Identifiers

PMID: 7852512
DOI: 10.1210/jcem.80.2.7852512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).PMID 7852512Read ↗

A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length.Semantic proximity Read ↗

CAG-repeat expansion in androgen receptor in Kennedy's disease is not a loss of function mutation.Semantic proximity Read ↗

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.Semantic proximity Read ↗

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.Semantic proximity Read ↗

Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Molecular analysis of the androgen receptor gene in Kennedy's disease. Report of two families and review of the literature.Semantic proximity Read ↗

Kennedy's disease: a clinicopathologic correlation with mutations in the androgen receptor gene.Semantic proximity Read ↗

Phenotypic diversity and testosterone-induced normalization of mutant L712F androgen receptor function in a kindred with androgen insensitivity.Semantic proximity Read ↗

Substitution of valine-865 by methionine or leucine in the human androgen receptor causes complete or partial androgen insensitivity, respectively with distinct androgen receptor phenotypes.Semantic proximity Read ↗

Kennedy disease in two sisters with biallelic CAG expansions of the androgen receptor gene.Semantic proximity Read ↗

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Androgen receptor mutation in Kennedy's disease.Semantic proximity Read ↗

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