Article
Molecular analysis of the androgen receptor gene in Kennedy's disease. Report of two families and review of the literature.
Hormone research - 1 Jan 1997
Lumbroso S, Lobaccaro J M, Vial C, Sassolas G, Ollagnon B, Belon C, Pouget J, Sultan C
Abstract excerpt
We have performed a molecular analysis of the androgen receptor gene in two families with suspected Kennedy's disease (spinal and bulbar muscular atrophy, SBMA) with the aim of making a firm diagnosis of the disease. The 2 patients studied were sporadic cases. Both presented clinical signs compat...
Topics
- Base Sequence
- DNA
- Deoxyribonuclease HpaII
- Electrophoresis, Agar Gel
- Humans
- Male
- Middle Aged
- Muscular Atrophy, Spinal
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Receptors, Androgen
- Repetitive Sequences, Nucleic Acid