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Article

Involvement of upstream stimulatory factor in regulation of the mouse Prnd gene coding for Doppel protein.

Biochimica et biophysica acta - 20 Dec 2005

Sepelakova Janka, Takacova Martina, Pastorekova Silvia, Kopacek Juraj

Abstract excerpt

Promoter of the Prnd gene coding for the Prion-like protein Doppel contains two critical cis-regulatory elements, NF-Y consensus motif and canonical E-box. Here, we studied a role of the upstream stimulatory factor (USF) in the E-box-mediated activation of Prnd transcription. Co-expression of USF-1 with the luciferase reporter gene driven by the -185/+27 Prnd promoter fragment resulted in several fold increase of...

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PMID: 16297464
DOI: 10.1016/j.bbaexp.2005.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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