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Article

Homozygosity mapping of the Werner syndrome locus (WRN).

Genomics - 1 Oct 1994

Nakura J, Wijsman E M, Miki T, Kamino K, Yu C E, Oshima J, Fukuchi K, Weber J L, Piussan C, Melaragno M I

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disorder characterized by the early onset of several age-related diseases. The locus for this disease was recently mapped to 8p12. We studied 27 WS kindreds of mixed ethnic origins, 26 of which were consanguineous. In 24 of these families, the affected subject was given the diagnosis of "definite" WS and affected subjects in the remaining 3 pedigrees were given the...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 8
Ethnicity
Genetic Linkage
Genetic Markers
Homozygote
Humans
Lod Score
Pedigree
Polymorphism, Genetic
Registries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Software

Werner Syndrome

Source

Identifiers

PMID: 7851888
DOI: 10.1006/geno.1994.1548

Genes

WRN
PLAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7851888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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