Article
Genetic linkage of Werner's syndrome to five markers on chromosome 8.
Nature - 20 Feb 1992
Goto M, Rubenstein M, Weber J, Woods K, Drayna D
Abstract excerpt
Werner's syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common. The WS mutation has pleiotropic effects, and patients and their cells show many differences compared with normals. Despite extensive study...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Japan
- Lod Score
- Werner Syndrome