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Article

Integrated mapping analysis of the Werner syndrome region of chromosome 8.

Genomics - 1 Sept 1994

Oshima J, Yu C E, Boehnke M, Weber J L, Edelhoff S, Wagner M J, Wells D E, Wood S, Disteche C M, Martin G M

Abstract excerpt

The Werner syndrome locus (WRN) is located at 8p11-p12. To facilitate eventual cloning of the WRN gene, a 10,000-rad radiation-reduced hybrid (RH) cell panel was generated to map genetic markers, sequence-tagged sites (STSs), and genes in this region. A hamster cell line carrying an intact human chromosome 8 was fused with another hamster cell line. Two sets of hybrid cell panels from 2 separate fusions were...

Topics

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 8
Genetic Markers
Genotype
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Lod Score
Molecular Sequence Data
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Werner Syndrome

Source

Identifiers

PMID: 7829057
DOI: 10.1006/geno.1994.1464

Genes

WRN
ANK1
FGFR1
GSR
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7829057-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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