Article
The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice.
Mutation research - 1 Jul 1992
Ward J B, Ammenheuser M M, Ramanujam V M, Morris D L, Whorton E B, Legator M S
Abstract excerpt
Benzene is a widely used chemical and common environmental contaminant. It is carcinogenic in man and animals and is genotoxic in mice, rats, and occupationally exposed humans at doses above one part per million. In order to evaluate the genotoxic effects of prolonged exposures to very low concentrations of benzene, we exposed CD-1 mice to benzene by inhalation for 22 h per day, seven days per week for six weeks...
Topics
- Administration, Inhalation
- Animals
- Benzene
- Dose-Response Relationship, Drug
- Female
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Male
- Mice
- Mice, Inbred Strains
- Mutagenicity Tests