Article
Characterization of the truncated thrombopoietin variants.
Biochemical and biophysical research communications - 24 Aug 1995
Wada T, Nagata Y, Nagahisa H, Okutomi K, Ha S H, Ohnuki T, Kanaya T, Matsumura M, Todokoro K
Abstract excerpt
Thrombopoietin (Tpo) is a specific cytokine which regulates megakaryocyte differentiation and maturation. We isolated a truncated mouse Tpo cDNA, the product of which turned out to function neither as an active Tpo variant nor as an antagonist. To define the functional domains of the Tpo molecule further, various truncated and point-mutated Tpo molecules were prepared and their biological activity was assayed. It...
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