Article
FMS mutations in myelodysplastic, leukemic, and normal subjects.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Ridge S A, Worwood M, Oscier D, Jacobs A, Padua R A
Abstract excerpt
The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1, the macrophage- and monocyte-specific growth factor. Codons 969 and 301 have been identified as potentially involved in promoting the transforming activity of FMS. Mutations at codon 301 are believed to lead to neoplastic transformation by ligand independence and constitutive tyrosine kinase activity of the receptor. The...
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