A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli.

doi:10.1128/jb.177.3.524-529.1995

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Article

A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli.

Journal of bacteriology - 1 Feb 1995

Jafri S, Urbanowski M L, Stauffer G V

Abstract excerpt

The DNA-binding protein MetR belongs to the LysR family of transcriptional activators and is required for expression of the metE and metH promoters in Escherichia coli. However, it is not known if this activation is mediated by a direct interaction of MetR with RNA polymerase. In a search for RNA polymerase mutants defective in MetR-mediated activation of the metE gene, we isolated a mutation in the alpha subunit...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Alleles
Bacterial Proteins
Base Sequence
DNA-Directed RNA Polymerases
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Lac Operon
Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Promoter Regions, Genetic

Trans-Activators

Transcription, Genetic

Transduction, Genetic

Source

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Identifiers

PMID: 7836282
DOI: 10.1128/jb.177.3.524-529.1995
PMCID: PMC176623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7836282-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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