Article
Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family.
Gene - 23 Jan 1995
Périer F, Radeke C M, Raab-Graham K F, Vandenberg C A
Abstract excerpt
A cDNA encoding a novel mammalian member of the Clp/HSP104 family was isolated from a mouse macrophage-like cell line (J774.1) cDNA library by suppression of the growth defect of a Saccharomyces cerevisiae trk1 trk2 double mutant. The full-length version of this cDNA, termed SKD3, encodes a putative 76-kDa protein of 677 amino acids (aa). The deduced aa sequence of the SKD3 polypeptide contains four ankyrin-like...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Cell Division
- DNA, Complementary
- Heat-Shock Proteins
- Mice
- Molecular Sequence Data
- Mutation