Article
Separation anxiety: the etiology of nondisjunction in flies and people.
Human molecular genetics - 1 Sept 1994
Hawley R S, Frazier J A, Rasooly R
Abstract excerpt
Two new studies examine the recombinational history of human chromosomes that nondisjoin at the first meiotic division in females. Our analysis of these studies suggests two possible etiologies of nondisjunction in terms of well-understood properties of chromosome mechanics. For both the X chromosome and for chromosome 21, 60-70% of nondisjoined chromosomes are derived from chiasmate bivalents, many of which...
Topics
- Animals
- Chromosome Aberrations
- Chromosomes, Human, Pair 21
- DNA Transposable Elements
- Drosophila melanogaster
- Female
- Humans
- Maternal Age
- Meiosis
- Models, Genetic
- Mutation
- Pregnancy