Article
Factor VIII:C increases after desmopressin in a subgroup of patients with autosomal recessive severe von Willebrand disease.
British journal of haematology - 1 Jan 1995
Castaman G, Lattuada A, Mannucci P M, Rodeghiero F
Abstract excerpt
Patients with severe von Willebrand disease (vWD) usually show no increase of factor VIII/von Willebrand factor (VIII/vWF) after desmopressin (DDAVP) infusion and the bleeding time (BT) remains markedly prolonged. We have tested the biological responsiveness to DDAVP in six patients, belonging to six different families, with phenotypic evidence for severe vWD. Baseline VIII:C ranged from 12 to 32IU/dl, ristocetin...
Topics
- Adolescent
- Adult
- Bleeding Time
- Deamino Arginine Vasopressin
- Factor VIII
- Female
- Genes, Recessive
- Humans
- Male
- Phenotype
- Tissue Plasminogen Activator