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Article

Molecular and phenotypic determinants of the response to desmopressin in adult patients with mild hemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2009

Castaman G, Mancuso M E, Giacomelli S H, Tosetto A, Santagostino E, Mannucci P M, Rodeghiero F

Abstract excerpt

BACKGROUND: The relationship of the biologic response to desmopressin with the F8 mutation and physiological characteristics has been poorly investigated in patients with mild hemophilia A. OBJECTIVES: We prospectively assessed the molecular and phenotypic determinants of the biologic response to desmopressin in a cohort of 50 patients with mild hemophilia A. METHODS: Up to 24 h after desmopressin, blood samples...

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Source

Identifiers

PMID: 19719828
DOI: 10.1111/j.1538-7836.2009.03595.x

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Molecular and phenotypic determinants of the response to desmopressin in adult patients with mild hemophilia A.PMID 19719828Read ↗

Genotype-Dependent Response to Desmopressin in Hemophilia A and Proposal of a Predictive Response Score.Semantic proximity Read ↗

Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD.Semantic proximity Read ↗

Response to desmopressin is strongly dependent on F8 gene mutation type in mild and moderate haemophilia A.Semantic proximity Read ↗

Inhibitors to Factor VIII in a Family with Mild Hemophilia: Molecular Characterization and Response to Factor VIII and DesmopressinSemantic proximity Read ↗

Desmopressin in moderate hemophilia A patients: a treatment worth considering.Semantic proximity Read ↗

Optimizing treatment of von Willebrand disease by using phenotypic and molecular data.Semantic proximity Read ↗

Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study.Semantic proximity Read ↗

von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD.Semantic proximity Read ↗

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The natural history of mild haemophilia: a 30-year single centre experience.Semantic proximity Read ↗

Biological effect of desmopressin in eight patients with type 2N ('Normandy') von Willebrand disease. Collaborative Group.Semantic proximity Read ↗

Factor VIII:C increases after desmopressin in a subgroup of patients with autosomal recessive severe von Willebrand disease.Semantic proximity Read ↗

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