A study of the vaccinia virus interferon-γ receptor and its contribution to virus virulence

doi:10.1099/0022-1317-83-8-1953

Article

A study of the vaccinia virus interferon-γ receptor and its contribution to virus virulence

1 Aug 2002

Abstract excerpt

Vaccinia virus (VV) strain Western Reserve gene B8R encodes a 43 kDa glycoprotein that is secreted from infected cells early in infection as a homodimer. This protein has amino acid similarity with the extracellular domain of cellular IFN-gamma receptor (IFN-gammaR) and binds and inhibits IFN-gamma from a wide range of species. Here we demonstrate that the B8R protein also inhibits equine IFN-gamma. The 5' end of...

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