Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.

doi:10.1006/geno.1994.1473

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Article

Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.

Genomics - 1 Sept 1994

Kamb A, Futreal P A, Rosenthal J, Cochran C, Harshman K D, Liu Q, Phelps R S, Tavtigian S V, Tran T, Hussey C

Abstract excerpt

The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer. VHR encodes a phosphatase with dual specificity for tyrosine and serine residues. Thus it is a plausib...

Topics

BRCA1 Protein
Base Sequence
Breast Neoplasms
Chromosomes, Human, Pair 17
DNA Mutational Analysis
DNA, Complementary
DNA, Neoplasm
Dual Specificity Phosphatase 3
Female
Genes
Genes, Tumor Suppressor
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Neoplasm Proteins

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 7829067
DOI: 10.1006/geno.1994.1473

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7829067-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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