Article
Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
Genomics - 1 Sept 1994
Kamb A, Futreal P A, Rosenthal J, Cochran C, Harshman K D, Liu Q, Phelps R S, Tavtigian S V, Tran T, Hussey C
Abstract excerpt
The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer. VHR encodes a phosphatase with dual specificity for tyrosine and serine residues. Thus it is a plausible candidate for a tumor suppressor gene such as BRCA1. To test this possibility, the VHR coding sequence was screened...
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