Article
Alterations in flightin phosphorylation in Drosophila flight muscles are associated with myofibrillar defects engendered by actin and myosin heavy-chain mutant alleles.
Biochemical genetics - 1 Aug 1994
Vigoreaux J O
Abstract excerpt
Flightin is a 20-kD myofibrillar protein found in the stretch-activated flight muscles of Drosophila melanogaster. Nine of the eleven isoelectric variants of flightin are generated in vivo by multiple phosphorylations. The accumulation of these isoelectric variants is affected differently by muta...
Topics
- Actin Cytoskeleton
- Actins
- Animals
- Cell Fractionation
- Drosophila Proteins
- Drosophila melanogaster
- Electrophoresis, Gel, Two-Dimensional
- Filamins
- Flight, Animal
- Gene Expression Regulation, Developmental
- Isoelectric Focusing
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- Myofibrils
- Myosins
- Phosphorylation
- Protein Precursors