Article
COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.
American journal of physiology. Cell physiology - 1 Aug 2011
Tanner Bertrand C W, Miller Mark S, Miller Becky M, Lekkas Panagiotis, Irving Thomas C, Maughan David W, Vigoreaux Jim O
Abstract excerpt
The indirect flight muscle (IFM) of insects is characterized by a near crystalline myofilament lattice structure that likely evolved to achieve high power output. In Drosophila IFM, the myosin rod binding protein flightin plays a crucial role in thick filament organization and sarcomere integrity. Here we investigate the extent to which the COOH terminus of flightin contributes to IFM structure and mechanical...
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