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Article

Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers.

American journal of physiology. Cell physiology - 1 Jan 2004

Henkin Josh A, Maughan David W, Vigoreaux Jim O

Abstract excerpt

Striated muscles across phyla share a highly conserved sarcomere design yet exhibit broad diversity in contractile velocity, force, power output, and efficiency. Insect asynchronous flight muscles are characterized by high-frequency contraction, endurance, and high-power output. These muscles have evolved an enhanced delayed force response to stretch that is largely responsible for their enhanced oscillatory work...

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Identifiers

PMID: 12954604
DOI: 10.1152/ajpcell.00257.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers.PMID 12954604Read ↗

COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.Semantic proximity Read ↗

A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles.Semantic proximity Read ↗

Site directed mutagenesis of Drosophila flightin disrupts phosphorylation and impairs flight muscle structure and mechanics.Semantic proximity Read ↗

Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.Semantic proximity Read ↗

Alterations in flightin phosphorylation in Drosophila flight muscles are associated with myofibrillar defects engendered by actin and myosin heavy-chain mutant alleles.Semantic proximity Read ↗

Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles.Semantic proximity Read ↗

Absence of the Z-disc Protein α-actinin-3 Impairs the Mechanical Stability of Actn3KO Mouse Fast- twitch Muscle Fibres without Altering their Contractile Properties or Twitch KineticsSemantic proximity Read ↗

Mutations in Drosophila myosin rod cause defects in myofibril assembly.Semantic proximity Read ↗

Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of <i>Actn3KO</i> mouse fast-twitch muscle fibres without altering their contractile properties or twitch kineticsSemantic proximity Read ↗

The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics.Semantic proximity Read ↗

Flightin is necessary for length determination, structural integrity, and large bending stiffness of insect flight muscle thick filaments.Semantic proximity Read ↗

Effects of tropomyosin deficiency in flight muscle of Drosophila melanogaster.Semantic proximity Read ↗

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