Article
[Virulence of rifampicin and quinolone resistant mutants of strains of plague microbe with Fra+ and Fra- phenotypes].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Apr 1994
Ryzhko I V, Shcherbaniuk A I, Samokhodkina E D, Tsuraeva R I, Mishn'kin B N, Kasatkina I V, Zhigalova T A
Abstract excerpt
Experiments with 15 highly virulent antigenically typical strains (Fra+) and 3 fraction-free strains (Fra-) of the plague microbe were conducted. It was demonstrated that a single exposure of the plague microbe to rifampicin or nalidixic acid (100 micrograms/ml) resulted in the formation of mutants (Rifr or Nalr) resistant to the drugs. The mutation frequency was 10(-10)-10(-8). All the Nalr mutants showed cross...
Topics
- 4-Quinolones
- Anti-Infective Agents
- Drug Resistance, Microbial
- Mutation
- Phenotype
- Rifampin
- Virulence
- Yersinia pestis