Article
[Doxycycline in the prevention of experimental plague induced by plague microbe variants].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Nov 1992
Samokhodkina E D, Ryzhko I V, Shcherbaniuk A I, Kasatkina I V, Tsuraeva R I, Zhigalova T A
Abstract excerpt
A comparative study was performed on the efficacy of doxycycline in experimental plague infection induced in albino mice by strain 231 of the plague microbe and its variant 231 Fra- deprived of the ability to produce the fraction I antigen. It was shown that the LD50 for strain 231 during animal treatment with doxycycline was significantly higher than that for variant 231 Fra-. Prophylaxis of the plague infection...
Topics
- Animals
- Antigens, Bacterial
- Doxycycline
- Genetic Variation
- Mice
- Plague
- Yersinia pestis