Article
[Chromosomal resistance of plague agent to quinolones].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Aug 1991
Kasatkina I V, Shcherbaniuk A I, Makarovskaia L N, Padeĭskaia E N
Abstract excerpt
The nature of increasing chromosomal resistance to quinolones was studied in a model of the plague microbe. Five virulent strains of the natural plague microbe (Y. pestis) were used in the experiment: 363 (1/1479), 231, 2385, 2442 and 2444. The one-stage procedure for isolation of the mutants was applied. It was shown that the frequency of the one-stage mutants resistant to oxalinic acid, pefloxacin and...
Topics
- Animals
- Chromosomes, Bacterial
- Culture Media
- Disease Models, Animal
- Drug Resistance, Microbial
- In Vitro Techniques
- Mice
- Models, Genetic
- Mutation
- Plague
- Quinolones