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Article

Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

American journal of human genetics - 1 Jan 1995

DeMeester C A, Bu X, Gray R J, Lusis A J, Rotter J I

Abstract excerpt

Lipoprotein (a) (Lp[a]) is a cholesterol-rich lipoprotein resembling LDL but also containing a large polypeptide designated apolipoprotein (a) (apo[a]). Its levels are highly variable among individuals and, in a number of studies, are strongly correlated with the risk of coronary artery disease (CAD). In an effort to determine which genes control Lp(a) levels, we have studied 25 multiplex families (comprising 298...

Topics

Alleles
Apolipoproteins
Apolipoproteins B
Apoprotein(a)
Chromosomes, Human, Pair 6
Coronary Disease
Electrophoresis, Gel, Pulsed-Field
Genes
Genetic Linkage
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Lipoprotein(a)

Minisatellite Repeats

Plasminogen

Source

Open in PubMed Open full text

Identifiers

PMID: 7825589
PMCID: PMC1801290

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7825589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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