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Article

HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus. SLE Study Group.

Rheumatology international - 1 Jan 1994

Yao Z, Seelig H P, Ehrfeld H, Renz M, Hartung K, Deicher H, Keller E, Nevinny-Stickel C, Albert E D

Abstract excerpt

To investigate a possible involvement of HLA-class II alleles in the genetic predisposition for the formation of anti-U1-nRNP antibody-in systemic lupus erythematosus (SLE), genomic DNA of 178 patients was typed for the DRB1, DQA1 and DQB1 alleles using a polymerase chain reaction (PCR) and non-radioactive-oligonucleotide typing. Antibodies against recombinant U1-nRNP proteins (U1-A-, U1-C- and 70K-protein) were...

Topics

Alleles
Antibodies, Anti-Idiotypic
Genes, MHC Class II
HLA-DQ Antigens
HLA-DR Antigens
Humans
Lupus Erythematosus, Systemic
Ribonucleoprotein, U1 Small Nuclear

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7824837
DOI: 10.1007/BF00300249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7824837-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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