Article
Defective binding of neutral lipids by a carboxyl-terminal deletion mutant of cholesteryl ester transfer protein. Evidence for a carboxyl-terminal cholesteryl ester binding site essential for neutral lipid transfer activity.
The Journal of biological chemistry - 13 Jan 1995
Wang S, Kussie P, Deng L, Tall A
Abstract excerpt
The plasma cholesteryl ester transfer protein (CETP, 476 amino acids) transfers cholesteryl ester (CE) from high density lipoprotein (HDL) to triglyceride-rich lipoproteins and plays a major role in HDL catabolism. Using deletional and site-directed mutagenesis, we previously showed that the carboxyl terminus of human CETP comprises the epitope of a neutralizing monoclonal antibody and is necessary for neutral...
Topics
- Animals
- Binding Sites
- Biological Transport
- CHO Cells
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Cholesterol Esters
- Cricetinae
- Glycoproteins
- Humans