Effects of second-site mutations on dominant interference by a human immunodeficiency virus type 1 envelope glycoprotein mutant.

doi:10.1128/JVI.69.2.1344-1348.1995

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Article

Effects of second-site mutations on dominant interference by a human immunodeficiency virus type 1 envelope glycoprotein mutant.

Journal of virology - 1 Feb 1995

Buchschacher G L, Freed E O, Panganiban A T

Abstract excerpt

We have demonstrated previously that a human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein containing a Val-to-Glu substitution at the second amino acid of the transmembrane glycoprotein gp41 (termed the 41.2 mutant) dominantly interferes with wild-type envelope-mediated syncytium f...

Topics

CD4 Antigens
HIV Envelope Protein gp120
HIV Envelope Protein gp41
HIV-1
Mutation
Structure-Activity Relationship
Viral Interference

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