Article
A trans-dominant mutation in human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41 inhibits membrane fusion when expressed in target cells.
Molecular membrane biology - 1 Jan 2000
Elson H F, Dimitrov D S, Blumenthal R
Abstract excerpt
A recombinant vaccinia virus was used to express a mutation in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120-gp41. In this mutant protein, the second amino acid in the N-terminal region of gp41 has been converted from a hydrophobic valine residue to the polar glutama...
Topics
- Antibodies, Monoclonal
- Base Sequence
- CD4 Antigens
- Gene Expression Regulation, Viral
- Genetic Vectors
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Lymphocytes
- Membrane Fusion
- Molecular Sequence Data
- Mutation
- Plasmids
- Recombination, Genetic
- Vaccinia virus