Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition.

doi:10.1128/JVI.72.1.209-217.1998

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Article

Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition.

Journal of virology - 1 Jan 1998

Rudensey L M, Kimata J T, Long E M, Chackerian B, Overbaugh J

Abstract excerpt

Simian immunodeficiency virus SIVMne, like human immunodeficiency virus, evolves from a macrophage-tropic, non-syncytium-inducing virus at early times in infection to a T-cell-tropic, syncytium-inducing, cytopathic virus population over the course of progression to AIDS. Because the viruses isola...

Topics

Amino Acid Sequence
Animals
Antibodies, Viral
Cells, Cultured
Chimera
Cytopathogenic Effect, Viral
Genes, Viral
Genetic Variation
Humans
Macaca
Macrophages
Molecular Sequence Data
Neutralization Tests

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, CCR5

Sequence Homology, Amino Acid

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Transfection

Source

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Identifiers

PMID: 9420217
DOI: 10.1128/JVI.72.1.209-217.1998
PMCID: PMC109366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9420217-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.