Article
Association analysis of the dopamine D2 receptor gene in Tourette's syndrome using the haplotype relative risk method.
American journal of medical genetics - 15 Sept 1994
Nöthen M M, Hebebrand J, Knapp M, Hebebrand K, Camps A, von Gontard A, Wettke-Schäfer R, Lisch S, Cichon S, Poustka F
Abstract excerpt
Comings et al. [1991: JAMA 266: 1793-1800] have recently reported a highly significant association between Tourette's syndrome (TS) and a restriction fragment length polymorphism (RFLP) of the dopamine D2 receptor gene (DRD2) locus. The A1 allele of the DRD2 Taq I RFLP was present in 45% of the Tourette patients compared with 25% of controls. We tried to replicate this finding by using the haplotype relative risk...
Topics
- Adolescent
- Adult
- Alleles
- Genotype
- Haplotypes
- Humans
- Polymorphism, Restriction Fragment Length
- Receptors, Dopamine D2
- Risk Factors
- Tourette Syndrome