Article
D2 dopamine receptor alleles do not influence severity of Tourette's syndrome. Results from four large kindreds.
Archives of neurology - 1 Apr 1994
Gelernter J, Pauls D L, Leckman J, Kidd K K, Kurlan R
Abstract excerpt
OBJECTIVE: We investigated the recently proposed hypothesis that the A1 allele of the Taq I polymorphic system at the D2 dopamine receptor gene (DRD2) influences the severity of Tourette's syndrome (TS). We have previously demonstrated that DRD2 is not linked to TS, establishing that it cannot be the major locus determining the susceptibility to develop TS. METHOD: We studied alleles at the DRD2 A system in...
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