D2 dopamine receptor alleles do not influence severity of Tourette's syndrome. Results from four large kindreds.

doi:10.1001/archneur.1994.00540160099012

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Article

D2 dopamine receptor alleles do not influence severity of Tourette's syndrome. Results from four large kindreds.

Archives of neurology - 1 Apr 1994

Gelernter J, Pauls D L, Leckman J, Kidd K K, Kurlan R

Abstract excerpt

OBJECTIVE: We investigated the recently proposed hypothesis that the A1 allele of the Taq I polymorphic system at the D2 dopamine receptor gene (DRD2) influences the severity of Tourette's syndrome (TS). We have previously demonstrated that DRD2 is not linked to TS, establishing that it cannot be...

Topics

Alleles
Genetic Linkage
Heterozygote
Homozygote
Humans
Receptors, Dopamine D2
Severity of Illness Index
Tourette Syndrome

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