Article
Association and linkage disequilibrium between a functional polymorphism of the dopamine-2 receptor gene and schizophrenia in a genetically homogeneous Portuguese population.
Molecular psychiatry - 1 Jan 2002
Schindler K M, Pato M T, Dourado A, Macedo A, Azevedo M H, Kennedy J L, Pato C N
Abstract excerpt
A functional polymorphism in the promoter region of the DRD2 gene has been found to be associated with schizophrenia in Japanese(1,2) and Swedish populations.(3) We attempted to replicate these findings in a genetically homogeneous Portuguese population using a family-based study design. Analysis of 78 trios revealed evidence for association between the -141 C Ins allele and schizophrenia using the haplotype...
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