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Article

No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families.

American journal of medical genetics - 31 May 1996

Barr C L, Wigg K G, Zovko E, Sandor P, Tsui L C

Abstract excerpt

Gilles de la Tourette Syndrome (TS) is neuropsychiatric disorder characterized by both motor and vocal tics affecting approximately 1/10,000 females and 1/2000 males. Because of the success of neuroleptics and other agents interacting with the dopaminergic system in the suppression of tics, a def...

Topics

Canada
Exons
Family
Genetic Linkage
Genetic Predisposition to Disease
Humans
Polymorphism, Genetic
Receptors, Dopamine D2
Receptors, Dopamine D4
Sequence Deletion
Tourette Syndrome
Tyrosine 3-Monooxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8725747
DOI: 10.1002/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO;2-P

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8725747-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families.PMID 8725747Read ↗

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Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome.Semantic proximity Read ↗

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The genetic basis of Gilles de la Tourette Syndrome.Semantic proximity Read ↗

Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome.Semantic proximity Read ↗

Association analysis between Tourette's syndrome and two dopamine genes (DAT1, DBH) in Taiwanese childrenSemantic proximity Read ↗

Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate.Semantic proximity Read ↗

Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test.Semantic proximity Read ↗

Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3).Semantic proximity Read ↗

Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.Semantic proximity Read ↗

Genome scan for linkage to Gilles de la Tourette syndrome.Semantic proximity Read ↗

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