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Article

Synonymous substitutions are clustered in enterobacterial genes.

Journal of molecular evolution - 1 Nov 1994

Eyre-Walker A

Abstract excerpt

The spatial distribution of synonymous substitutions in enterobacterial genes is investigated. It is shown that synonymous substitutions are significantly clustered in such a way that a synonymous substitution in one codon elevates the rate of synonymous substitution in an adjacent codon by about 10%. The level of clustering does not appear to be related to the level of gene expression, and it is restricted to a...

Topics

Base Sequence
Cluster Analysis
Enterobacteriaceae
Escherichia coli
Genes, Bacterial
Genetic Code
Genetic Variation
Molecular Sequence Data
Mutagenesis, Site-Directed
Recombination, Genetic
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

Source

Identifiers

PMID: 7807534
DOI: 10.1007/BF00173413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7807534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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