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Article

Marek's disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype.

PLoS pathogens - 1 Oct 2021

Trapp-Fragnet Laëtitia, Schermuly Julia, Kohn Marina, Bertzbach Luca D, Pfaff Florian, Denesvre Caroline, Kaufer Benedikt B, Härtle Sonja

Abstract excerpt

Marek's disease virus (MDV) is an alphaherpesvirus that causes immunosuppression and deadly lymphoma in chickens. Lymphoid organs play a central role in MDV infection in animals. B-cells in the bursa of Fabricius facilitate high levels of MDV replication and contribute to dissemination at early stages of infection. Several studies investigated host responses in bursal tissue of MDV-infected chickens; however, the...

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Identifiers

PMID: 34673841
DOI: 10.1371/journal.ppat.1010006
PMCID: PMC8562793

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