Article
Expression of a myosin regulatory light chain phosphorylation site mutant complements the cytokinesis and developmental defects of Dictyostelium RMLC null cells.
The Journal of cell biology - 1 Dec 1994
Ostrow B D, Chen P, Chisholm R L
Abstract excerpt
In a number of systems phosphorylation of the regulatory light chain (RMLC) of myosin regulates the activity of myosin. In smooth muscle and vertebrate nonmuscle systems RMLC phosphorylation is required for contractile activity. In Dictyostelium discoideum phosphorylation of the RMLC regulates bo...
Topics
- Actins
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Compartmentation
- Cell Division
- Dictyostelium
- Enzyme Activation
- Fluorescent Antibody Technique
- Genetic Complementation Test
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Myosin-Light-Chain Kinase
- Myosins
- Phosphorylation
- Recombinant Proteins