Article
Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently.
Blood - 15 Aug 1995
Kumaki S, Ochs H D, Timour M, Schooley K, Ahdieh M, Hill H, Sugamura K, Anderson D, Zhu Q, Cosman D
Abstract excerpt
X-linked severe combined immunodeficiency (XSCID) is characterized by absent or profoundly reduced numbers of T cells and normal numbers of B cells in the circulation. Affected patients have mutations of the interleukin-2 (IL-2) receptor gamma chain gene. Using Epstein-Barr virus-transformed B-lymphoblastoid cell lines (B-LCLs) established from two unrelated XSCID patients, we could show that neither expressed...
Topics
- B-Lymphocytes
- Base Sequence
- Cell Line
- DNA Primers
- Endocytosis
- Female
- Humans
- In Vitro Techniques
- Interleukin-15
- Interleukins
- Male