Article
Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype.
The Journal of biological chemistry - 25 Mar 1993
Wadhwa R, Kaul S C, Ikawa Y, Sugimoto Y
Abstract excerpt
A novel 66-kDa protein, named p66mot-1, is identified to be associated with cellular mortality by virtue of its presence in cytosolic fractions of serially passaged mouse embryonic fibroblasts (MEF) and the mortal hybrids obtained by the fusion of mortal (MEF) and immortal (MN48-1, derivative of NIH 3T3) cells. Immortal cells lack this protein in their cytosolic fractions. cDNA cloning and homology search placed...
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